Shopify is designed for small to medium-sized businesses, while Shopify Plus caters to high-volume enterprises. Shopify Plus offers advanced features like dedicated account managers, custom checkout experiences, higher API limits, and automation tools like Shopify Flow. It also supports multi-store management and deeper integrations. While regular Shopify is sufficient for most businesses, Shopify Plus is ideal for large brands needing enterprise-grade scalability, flexibility, and support.